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You should start to see improvements within a few days to a week, however if you do not feel the effects after 2-3 injection sessions, then it is likely that you were and are not deficient in B12
The following screen shots are of NICE Guidelines Do not do recommendations for CFS/ME It is a really tricky page to find (and has a habit of hiding) so here is the link
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They can happen very quickly or very slowly
Signs of Degradation Don't use the reconstituted solution if it appears cloudy, contains visible particles that don't dissolve with gentle swirling, or has changed color
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